Dar Weiss Lab
Tel Aviv University

Scholar Profile
Dar Weiss’ goal is to find engineering solutions at the interface between cardiovascular biology and mechanics that will positively impact human health.

Dr. Weiss dedicated his PhD research to designing a short peripheral catheter for intravenous procedures, at the Cardiovascular System and Bioengineering Laboratory at Tel Aviv University.

When tested using in vitro cell-culture and drug release experiments, advanced imaging techniques, in silico computational models, and an in vivo preclinical study in a large animal, the catheter was shown to minimize biomechanical interaction with the vein wall during the indwelling period. It also reduced the risk of vein inflammation and thrombosis, and distributed drugs favorably within the vein. The catheter was patented and attracted public and scientific attention.

Dr. Weiss’ lab at the Biomedical Engineering Department at Tel Aviv University focuses on developing therapeutics for cardiovascular diseases, and particularly on the mechanobiological mechanism responsible for their onset and progression. For example, aneurysms that progress to rupture of the thoracic aorta, the largest blood vessel in the body, are catastrophic events, and a significant cause of mortality worldwide. He hopes to develop a new therapeutic approach to that disease, focusing on translational discoveries in the field of cardiovascular biomechanics, especially using nanoparticle therapy.

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Dr. Weiss’ lab works with cell biologists, cardiologists, and other medical and basic science researchers. Using multiscale and multidisciplinary approaches including biomechanics, state-of-the-art imaging and transcriptomics, the lab seeks to better understand the etiology and treatment of cardiovascular disease.

At Yale University’s Vascular Mechanics and Mechanobiology Laboratory, Dr. Weiss served as a postdoctoral associate, and later an associate research scientist. He used novel optics-based techniques, optical coherence tomography imaging, and inverse modelling to reveal for the first time the mechanobiological mechanisms that precede aortic damage.

Principal Investigator
Dr. Dar Weiss
Zuckerman Faculty Scholar
Established 2024