Shani Stern

Congratulations to Zuckerman Faculty Scholar Shani Stern on publishing  a new study in October’s Journal of Controlled Release, The study, Music enhances lipid nanoparticle brain delivery and mRNA transfection in brain cells,  introduces a non-invasive, music-based approach to bypass the blood-brain barrier and improve the delivery of therapeutic lipid nanoparticles to the brain.

Dr. Stern’s lab for Precision Disease Modeling at the University of Haifa’s Department of Neurobiology, uses molecular biology combined with biophysical, electrophysiological, and numerical simulation platforms to facilitate the use of induced pluripotent stem cell technologies, where adult cells from human patients are reprogrammed into pluripotent stem cells.

Abstract:
Delivering therapeutic agents to the brain, particularly to neurons, is crucial for advancing treatments for neurological diseases.  The study introduces a non-invasive approach using music to enhance the delivery of lipid nanoparticles (LNPs) to the brain, potentially improving drug uptake. While LNPs have demonstrated significant potential in systemic delivery, various strategies have been explored to enhance their brain delivery.