Ido Goldstein

Congratulation to Ido Goldstein, Assistant Professor and Zuckerman Faculty Scholar at The Hebrew University of Jerusalem, on the publication of  Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences, in Nature Reviews Endocrinology,  a comprehensive study on the hormonal control of the hepatic fasting response.

The study focused on specific hormones that drive hepatic fuel production and how their coordinated actions shape the body’s physiological response to fasting.

Abstract
Upon fasting, mammals undergo a fasting response in which the liver’s main role is producing fuel (glucose and ketone bodies) to supply extra-hepatic tissues. Glucose is produced by glycogenolysis and gluconeogenesis, and ketone bodies are produced by ketogenesis, which is preceded by lipolysis and fatty acid oxidation. Hepatic fuel

production during fasting is controlled by hormonal and metabolic  cues, collectively termed  ‘fasting cues’… that directly signal hepatocytes, and whose plasma levels increase upon fasting…