Lior Lobel

Congratulations to Lior Lobel, Zuckerman Faculty Scholar at Bar-Ilan University’s Faculty of Life Sciences, on publishing “Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit” in Immunity. The study found that sulfur amino acids in the diet can reshape the gut environment in ways that help the immune system fight colon cancer. In mouse models, the diet increased mucus thickness, expanded the mucus-dwelling bacterium Mucispirillum schaedleri, and activated an immune signaling pathway that recruited dendritic cells and strengthened anti-tumor responses.

Abstract:
The efficacy of immune checkpoint inhibitors (ICIs) in colon cancer (CC) is limited by the tolerogenic immune landscape of both the tumor and the intestine. Here, we investigated the impact of microbial metabolic pathways associated with ICI responsiveness on anti-tumor immunity in CC.