Dekel Rosenfeld

Zuckerman Faculty Scholar Dekel Rosenfeld, Assistant Professor at Tel Aviv University’s Sagol School of Neuroscience, published Nanoparticles- Mediated Modulation of TRP Channels: Advances and Therapeutic Potential, in Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology.  Nanoparticles can be used to activate ion channels with high precision to modulate cell signaling. The approach supports the development of minimally invasive therapeutic strategies and advanced nanotechnologies and may enable new interventions for pain as well as temperature.

Abstract:
Nanoparticles have emerged as promising tools for targeting and activating ion channels that serve as transducers for external signals. Their nanoscale dimensions enable targeted activation of ion channels at the cellular or subcellular level, offering unprecedented opportunities to control biological cell signaling. Recent works have demonstrated nanoparticle-mediated stimulation based on optical, electrical, and magnetic external signals, highlighting their potential to serve as minimally invasive therapeutics. In addition, there is an increasing need to identify relevant ion channels and their physiological role in advancing emerging nanotechnologies.